HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry
نویسندگان
چکیده
منابع مشابه
HDL modification by secretory phospholipase A(2) promotes scavenger receptor class B type I interaction and accelerates HDL catabolism.
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A(2) (sPLA(2)) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice overexpressing sPLA(2) have reduced HDL levels. Studies were performed to define the mechanism for the HDL reduction in these mice. HDL is...
متن کاملScavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems.
Scavenger receptors (SRs) are defined as cell surface membrane proteins that bind chemically modified lipoproteins, such as acetylated LDL (AcLDL) and oxidized LDL (OxLDL), and often many other types of ligands (1–3). Initially, scavenger receptor activity was identified as “AcLDL receptor activity” by Brown, Goldstein, and colleagues (2), who were developing an in vitro model for the depositio...
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Scavenger receptor B type I (SR-BI) plays an important role in mediating cholesterol exchange between cells, high-density lipoprotein (HDL) cholesterol, and other lipoproteins. SR-BI in hepatocytes is essential for reverse cholesterol transport and biliary secretion of HDL cholesterol; thus, it is atheroprotective. More recently, it has been discovered that the HDL-SR-BI tandem serves other fun...
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ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2020
ISSN: 2522-5812
DOI: 10.1038/s42255-020-00324-0